323 Main Street

The landmark James Pharmacy building located on vibrant Main Street is fully occupied, operating as the James Pharmacy Bed & Breakfast and separately rented main level bistro. Anna James, daughter of a slave and the first African American female pharmacist owned, operated and resided at the iconic pharmacy for decades. Her niece, noted novelist Anna Petry, was born here and assisted Miss James. The main floor restaurant retains the historic pharmacy built-ins and soda fountain. Arched glass windows offer Main Street views. Three well-appointed, upscale B&B guest rooms have fully renovated baths and gas fireplaces. Innkeeper quarters are on the main level. Extensive updates and renovations were completed, bringing it to current standards while preserving its beauty and historic architecture. A full basement houses mechanicals, exceptional storage and restaurant clean storage. Old Saybrook is a popular weekend destination. A short stroll on sidewalk-lined streets leads to restaurants, shops, The Kate cultural arts center and Saybrook Station just 2 hours from NY/Boston. Find exceptional beaches, boating, Fenwick or Fox Hopyard Golf a short drive. A vibrant Chamber of Commerce works tirelessly ensuring Old Saybrook businesses have the support they need with Main Street events throughout the year. Limited area lodging ensures the James Pharmacy Bed & Breakfast and restaurant are an option with provenance year-round.